Aldosterone & Hearing

Alternative treatment for hearing loss

Currently there is intriguing data that aldosterone supplementation may improve hearing. For those with hearing loss and balance disorders, this advancement could significantly improve quality of life. Aldosterone does not have the side effects of the current treatment with steroids (prednisone/prednisolone/dexamethasone) and may better address the underlying cause of hearing and vestibular disease.

Anatomy of the ear

Historical Treatment

Due to their anti-inflammatory and immune suppressive functions, glucocorticoids (steroids) have traditionally been used for suspected cases of inner ear inflammation – called immune mediated inner ear disease. Glucocorticoid treatment affects many areas of the body, and alters the feedback loop that naturally regulates the levels of glucocorticoids that result in homeostasis. For example, glucocorticoid ear drops greatly decrease natural levels of cortisol and in some people it may take a year for normal levels to return.

The status quo has been shaken in recent years due mainly to the work of two researchers in the U.S.: David Trune of the Oregon Health & Science University and Robert Frisina of Rochester Institute of Technology. In a 2012 review of corticosteroid treatment for hearing loss and balance disorders, Trune & Canlon indicate that there are a number of misconceptions regarding the use of steroids. Efficacy of steroid use is equivocal, due to the complicated nature of hearing problems, small sample sizes, spontaneous recovery and little information about the underlying cause of the hearing and vestibular problem. Other studies have questioned the anti-inflammatory and immune suppressive role of steroids to treat hearing and balance problems, and indicate that the mechanism of action may actually be sodium ion transport (Trune et al., 2000).

Aldosterone and hearing

This is where aldosterone comes in. Aldosterone is a naturally-occurring hormone called a mineralocorticoid – a type of steroid – which is produced in the adrenal glands. It influences sodium and potassium transport, which are important for hearing. As we age, aldosterone levels usually decrease. Some people also have low aldosterone levels due to other problems.

Frisina and colleagues reported in 2005 that aldosterone levels were significantly different in people with normal hearing and those with age-related hearing loss, called presbycusis. The authors concluded that aldosterone may have a protective effect on hearing. Aldosterone has been shown to be effective against Meniere’s disease which produces excess fluid in the inner ear (Pappas & Banyas, 1991). Synthetic aldosterone (fludrocortisone) plus low-dose prednisolone was effective at treating hearing loss in mice (Trune & Kempton, 2010). Thus, aldosterone may be a useful treatment for both immune-mediated and age-related hearing loss.

Aldosterone is not approved to treat hearing loss yet. An ongoing clinical trial using fludrocortisone for sudden hearing loss is being conducted by the Oregon Health and Sciences University. However, a physician in Washington, Dr. Jonathan Wright, has prescribed aldosterone to patients, but he has not published his findings. More information on Dr. Wright’s work can be found in his article “Take control of your hearing loss”.

Before you start treatment with aldosterone, keep in mind that its function is on sodium and calcium transport, and so aldosterone may affect blood pressure and too much increases the risk of stroke. Keeping aldosterone levels within the normal range is thus important.

The Parsemus Foundation urges continued evaluation of aldosterone treatment for hearing and balance disorders. If the effect is confirmed, this simple treatment can begin helping the millions of people with hearing loss.

Further study:

Frisina RD. (2009) Age-related hearing loss: Ear and brain mechanisms. International Symposium on Olfaction and Taste: Ann. N.Y. Acad. Sci. 1170: 708–717.

Frisina RD. (2012). Hormones and hearing: Too much or too little of a good thing can be ototoxic. Seminars in Hearing 33:231-241. Free full text.

Frisina RD, Frisina DR.(2013). Physiological and neurobiological bases of age-related hearing loss: biotherapeutic implications.Am J Audiol. 22(2):299-302.

Pappas DG, Banyas JB. (1991) A newly recognized etiology of Meniere’s syndrome. A preliminary report. Acta OtolaryngolSuppl 485:104–107.

Trune DR, Canlon B. (2012) Corticosteroid therapy for hearing and balance disorders. Anatomical Rec. 295:1928-1943. Free full text.

Trune DR, Kempton JB. (2010). Low dose combination steroids control autoimmune mouse hearing loss. J. Neuroimmunol 229(1-2):140-145. Free full text.

Trune DR, Kempton JB, Kessi M. (2000) Aldosterone (mineralocorticoid) equivalent to prednisolone (glucocorticoid) in reversing hearing loss in MRL/MpJ-FASlpr autoimmune mice. Laryngoscope 110:1902-1906.

Additional links:

Sources for aldosterone: Acros Organics and Sigma Aldrich

In the news: Curing hearing loss with hormone therapy Dr. Nor Ashikin Mokhatar, The Star/Asia News Network, April 15, 2013