Breast Cancer Prevention

Breast cancer prevention

Early-stage research into a way to clear out precancerous changes in the breast ducts, without surgery

Parsemus Foundation encourages research on the intraductal approach to early breast cancer– preventing, or eliminating, early cellular changes in the milk ducts (where the great majority of breast cancers start).

The Dr. Susan Love Research Foundation has taken the lead in this research (see blog post), studying the infusion of chemo drugs into the ductal tree through the nipple openings, as an alternative to surgery. The idea is that like Drano, the cleaner goes right to where the problem is found– and if caught early, before they have broken out of the ducts, precancerous changes (ductal carcinoma in situ, DCIS) could be treated without subjecting women to lumpectomy surgery.

Unfortunately, the chemo drugs themselves seem to have caused some cancers over time according to a study published in 2011. Since then, the Dr. Susan Love Foundation’s research has focused on other high-tech approaches, with the most recent collaboration showing siRNA (small interfering RNA, a class of double-stranded RNA molecules), effective intraductally in mice. Find link for the full text of this 2014 study at the end of Dr. Susan Love Research Foundation blog post.

DCIS

Advanced ductal carcinoma in situ. Photo credit www.breastpathology.info

Parsemus Foundation believes ethyl alcohol shows promise to achieve a similar effect and should be compared head-to-head with more expensive approaches such as siRNA. If successful, this approach would be an instantly-available alternative to surgery for women in resource-limited settings around the world. Though our budget is small, we welcome inquiries from researchers interested in conducting a cost-effective preclinical study (to European animal-care standards; see Animal Welfare Standards) or clinical study.